Main Article Content

Abstract

Introduction:The birth of tissue engineering as a new dentistry sphere opened up new horizons and created a platform for the introduction of innovative and effective methods of regenerating dental tissues and structures. Aim of this work is to summarize recent advances of tissue engineering in dental applications. Methods: Search was conducted through MEDLINE, Google Scholar, and PubMed as well, a sort of healthcare metadata that emphasizes, health-focused content. Results: Recent advancements in tissue engineering have enhanced the potential for creating new biomaterials. Conclusion: Several strategies are under investigation including techniques such as stem cell use, growth factor application, and scaffold grafting.  


Key words: Dental tissue engineering, regenerative dentistry, dental implants, biocompatible materials

Keywords

Dental tissue engineering, regenerative dentistry, dental implants, biocompatible materials

Article Details

How to Cite
Assarian , A. ., Almudarris, B. ., Tarek, A. ., Alqaderi , F. ., Alahmari, M., & Abdelmagyd, H. (2025). Recent advances of tissue engineering in dental applications. A literature review. Journal of Contemporary Dental Sciences, 2(2), 10–20. Retrieved from https://jcds.qu.edu.sa/index.php/JCDS/article/view/2373

References

  1. Galler KM, D'Souza RN, Hartgerink JD. Biomaterials and their potential applications for dental tissue engineering. Journal of Materials Chemistry. 2010;20(40):8730-46.
  2. Malhotra N, Kundabala M, Acharya S. Current strategies and applications of tissue engineering in den-tistry–A review part 1. Dental update. 2009;36(9):577-82.
  3. Boeckel DG, Shinkai RSA, Grossi ML, Teixeira ER. Cell culture–based tissue engineering as an alter-native to bone grafts in implant dentistry: a literature review. Journal of Oral Implantology. 2012;38(S1):538-45.
  4. Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engi-neering and regenerative medicine. Annals of Medicine. 2017;49(8):644-51.
  5. MORO JdS, BARCELOS RCS, TERRA TG, DANESI CC. Tissue engineering perspectives in dentis-try: review of the literature. RGO-Revista Gaúcha de Odontologia. 2018;66:361-7.
  6. Rosa V, Della Bona A, Cavalcanti BN, Nör JE. Tissue engineering: from research to dental clinics. Dental Materials. 2012;28(4):341-8.
  7. Abou Neel EA, Chrzanowski W, Salih VM, Kim H-W, Knowles JC. Tissue engineering in dentistry. Journal of dentistry. 2014;42(8):915-28.
  8. Matichescu A, Ardelean LC, Rusu L-C, Craciun D, Bratu EA, Babucea M, et al. Advanced biomateri-als and techniques for oral tissue engineering and regeneration—a review. Materials. 2020;13(22):5303.
  9. Cristaldi M, Mauceri R, Tomasello L, Pizzo G, Pizzolanti G, Giordano C, et al. Dental pulp stem cells for bone tissue engineering: a review of the current literature and a look to the future. Regenerative Medi-cine. 2018;13(2):207-18.
  10. Malhotra N, Kundabala M, Acharya S. Current Strategies and Applications of Tissue Engineering in Dentistry–A Review Part 2. Dental update. 2009;36(10):639-46.
  11. Jazayeri HE, Fahmy MD, Razavi M, Stein BE, Nowman A, Masri RM, et al. Dental applications of natural‐origin polymers in hard and soft tissue engineering. Journal of Prosthodontics. 2016;25(6):510-7.
  12. Sharma S, Srivastava D, Grover S, Sharma V. Biomaterials in tooth tissue engineering: a review. Jour-nal of clinical and diagnostic research: JCDR. 2014;8(1):309.
  13. Obregon F, Vaquette C, Ivanovski S, Hutmacher D, Bertassoni L. Three-dimensional bioprinting for regenerative dentistry and craniofacial tissue engineering. Journal of dental research. 2015;94(9_suppl):143S-52S.
  14. Moussa DG, Aparicio C. Present and future of tissue engineering scaffolds for dentin‐pulp complex regeneration. Journal of tissue engineering and regenerative medicine. 2019;13(1):58-75.
  15. Bakhshandeh B, Zarrintaj P, Oftadeh MO, Keramati F, Fouladiha H, Sohrabi-Jahromi S, et al. Tissue engineering; strategies, tissues, and biomaterials. Biotechnology and genetic engineering reviews. 2017;33(2):144-72.
  16. Fernandes G, Yang S. Application of platelet-rich plasma with stem cells in bone and periodontal tis-sue engineering. Bone Research. 2016;4(1):1-21.
  17. Eltom A, Zhong G, Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: a review. Advances in materials science and engineering. 2019;2019.
  18. Romero R. Engineering a biomimetic periosteum on cortical bone allografts for the reconstruction of critical-sized bone defects in mice: Colorado State University; 2017.
  19. Park H. Dense Collagen Scaffolds for Bone and Ligament Tissue Engineering: McGill University (Canada); 2021.
  20. Rezai Rad M, Hosseinpour S, Ye Q, Yao S. Dental tissues originated stem cells for tissue regeneration. Regenerative Approaches in Dentistry: An Evidence-Based Perspective. 2021:9-33.
  21. Khorasani HR, Sanchouli M, Mehrani J, Sabour D. Potential of bone-marrow-derived mesenchymal stem cells for maxillofacial and periodontal regeneration: a narrative review. International Journal of Dentis-try. 2021;2021.
  22. Spiller KL, Vunjak-Novakovic G. Clinical translation of controlled protein delivery systems for tissue engineering. Drug delivery and translational research. 2015;5:101-15.
  23. Briquez PS, Clegg LE, Martino MM, Gabhann FM, Hubbell JA. Design principles for therapeutic an-giogenic materials. Nature Reviews Materials. 2016;1(1):1-15.
  24. Wilting J, Männer J. Vascular embryology. Hemangiomas and vascular malformations: an atlas of di-agnosis and treatment. 2015:3-19.
  25. Tirone M. Endothelial-mesenchymal transition and the immune system: an evolving paradigm in mus-cle fibrosis and heterotopic ossification. 2017.
  26. Jianru Y, MeiLe L, Yang Y, Zheng W, Yu L, Zhao Z. Static compression regulates OPG expression in periodontal ligament cells via the CAMK II pathway. Journal of Applied Oral Science. 2015;23:549-54.
  27. Caetano AJ, Redhead Y, Karim F, Dhami P, Kannambath S, Nuamah R, et al. Spatially resolved tran-scriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10. Elife. 2023;12:e81525.
  28. Eliaz N, Metoki N. Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials. 2017;10(4):334.
  29. Canillas M, Pena P, de Aza AH, Rodríguez MA. Calcium phosphates for biomedical applications. Bo-letín de la Sociedad Española de Cerámica y Vidrio. 2017;56(3):91-112.
  30. Kim S, Hwangbo H, Chae S, Lee H. Biopolymers and their application in bioprinting processes for dental tissue engineering. Pharmaceutics. 2023;15(8):2118.
  31. Amrollahi P, Shah B, Seifi A, Tayebi L. Recent advancements in regenerative dentistry: A review. Ma-terials Science and Engineering: C. 2016;69:1383-90.
  32. Nadig RR. Stem cell therapy–Hype or hope? A review. Journal of Conservative Dentistry. 2009;12(4):131-8.
  33. Duan H, Gong M, Zhang Q, Huang X, Wan B. Research on sleep status, body mass index, anxiety and depression of college students during the post-pandemic era in Wuhan, China. Journal of Affective Disor-ders. 2022;301:189-92.
  34. Lorencetti-Silva F, Sales LS, Lamarque GdCC, Caixeta GA, Arnez MFM, Faccioli LH, et al. Effects of inflammation in dental pulp cell differentiation and reparative response. Frontiers in Dental Medicine. 2022;3:942714.
  35. da Silva FL, de Campos Chaves Lamarque G, de Oliveira FMMPC, Nelson-Filho P, da Silva LAB, Segato RAB, et al. Leukotriene b4 loaded in microspheres regulate the expression of genes related to odon-toblastic differentiation and biomineralization by dental pulp stem cells. BMC Oral Health. 2022;22(1):45.
  36. Silva PAO, Lima SMdF, Martins DCM, Amorim IA, Lacorte C, de Almeida JA, et al. Concentrated MTA Repair HP reduced biofilm and can cause reparative action at a distance. International Endodontic Journal. 2021;54(10):1925-36.
  37. Soares DG, Bordini EAF, Bronze-Uhle ES, Cassiano FB, Silva ISP, Gallinari MdO, et al. Chitosan-calcium-simvastatin scaffold as an inductive cell-free platform. Journal of Dental Research. 2021;100(10):1118-26.
  38. de Cara SPHM, Origassa CST, de Sá Silva F, Moreira MSN, de Almeida DC, Pedroni ACF, et al. An-giogenic properties of dental pulp stem cells conditioned medium on endothelial cells in vitro and in rodent orthotopic dental pulp regeneration. Heliyon. 2019;5(4).
  39. Hameed MH, Gul M, Ghafoor R, Badar SB. Management of immature necrotic permanent teeth with regenerative endodontic procedures-a review of literature. J Pak Med Assoc. 2019;69(10):1514-20.
  40. Yu S, Chen H, Gao B. Potential therapeutic effects of exosomes in regenerative endodontics. Archives of oral biology. 2020;120:104946.
  41. .Sugiaman VK, Djuanda R, Pranata N, Naliani S, Demolsky WL, Jeffrey. Tissue engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and collagen matrix, regulated by growth factor in regenerating the dental pulp. Polymers. 2022;14(18):3712.
  42. Agarwal KM, Singh P, Mohan U, Mandal S, Bhatia D. Comprehensive study related to advancement in biomaterials for medical applications. Sensors International. 2020;1:100055.
  43. Masson‐Meyers DS, Tayebi L. Vascularization strategies in tissue engineering approaches for soft tis-sue repair. Journal of tissue engineering and regenerative medicine. 2021;15(9):747-62.
  44. Tian T, Zhang T, Lin Y, Cai X. Vascularization in craniofacial bone tissue engineering. Journal of den-tal research. 2018;97(9):969-76.
  45. Wu V, Helder MN, Bravenboer N, Ten Bruggenkate CM, Jin J, Klein-Nulend J, et al. Bone tissue re-generation in the oral and maxillofacial region: a review on the application of stem cells and new strategies to improve vascularization. Stem cells international. 2019;2019.
  46. Dissanayaka WL, Zhang C. The role of vasculature engineering in dental pulp regeneration. Journal of Endodontics. 2017;43(9):S102-S6.
  47. Yang G, Mahadik B, Choi JY, Fisher JP. Vascularization in tissue engineering: fundamentals and state-of-art. Progress in Biomedical Engineering. 2020;2(1):012002.